Learn how to effectively use Ortho's Home Defense Ant, Roach & Spider Killer to protect your home from pests safely and efficiently.
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Home Defense Ant, Roach & Spider Killer by Ortho

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With over 20 years of experience, Anchor Pest offers personalized, chemical-safe yearly subscriptions, protecting homes and businesses across Manchester and surrounding counties with ongoing peace of mind.
Before you begin, remove pets and children from the area you plan to treat, and open windows for ventilation if possible. Wear disposable gloves to avoid getting the product on your skin. Place any food away from the treatment area and cover kitchen utensils or surfaces where food is prepared.
Shake the bottle well to ensure the ingredients are mixed. If your spray comes with a safety clip or lock, remove or disengage it according to the label instructions. Test the sprayer briefly into a sink or onto a disposable napkin to make sure it sprays evenly.
Look for places where you have seen ants, roaches, or spiders, as well as any cracks, crevices, or gaps in walls, windows, doors, and baseboards. Focus on corners, behind appliances, under sinks, around trash cans, and in cabinets.
Hold the bottle about 12 inches (30 cm) from the surface you want to treat. Spray a light, even coating directly onto baseboards, edges of floors, entry points, and other places where insects have been seen or are likely to enter. Avoid creating puddles or spraying excessively—just enough to slightly moisten the area.
Allow sprayed surfaces to dry completely before letting pets or children enter the area, or before touching treated surfaces. This usually takes about 30 minutes to 1 hour. Wash your hands thoroughly after use, even if you wore gloves.
Check treated areas every few weeks. If you continue to see ants, roaches, or spiders, repeat the application as needed by following the same steps. Store the spray bottle upright in a cool, dry place out of reach of children and pets. Make sure the nozzle is turned to “OFF” if there is a lock setting.
Professional pest control eliminates troubles immediately. Our safe, effective treatments protect your loved ones from dangerous diseases.

Call now for same-day, eco-friendly pest control
With over 20 years of experience, Anchor Pest offers personalized, chemical-safe quarterly subscriptions, protecting homes and businesses across Manchester and surrounding counties with ongoing peace of mind.
Home Defense Ant, Roach & Spider Killer by Ortho is a household insecticide spray designed to help people control and kill common crawling insects inside and around their homes. It is a ready-to-use aerosol product, which means you do not have to mix or dilute anything—just spray it as directed on bugs and on places where insects may enter or hide. The “Home Defense” in the name indicates the product’s main purpose: to protect your living spaces from unwanted pests that can invade, contaminate food, or become a nuisance.
This spray is specially formulated to work on a variety of household pests, including:
This product contains chemicals specifically made to kill insects either on contact or through residual action. That means:
You can generally use Home Defense Ant, Roach & Spider Killer by Ortho in most indoor spaces and sometimes in outdoor areas right next to your home. Typical areas include:
While this product is tested and generally approved for home use, it is still a pesticide and should be used carefully. The chemicals inside can be harmful if you breathe in the spray, get it on your skin, or if pets or young children touch treated surfaces before they dry. It is meant to be used exactly as the label says—avoiding direct contact with food, dishes, pet areas, or surfaces frequently touched by children.
Home Defense Ant, Roach & Spider Killer by Ortho usually comes in an easy-to-hold aerosol can. Some varieties feature a “continuous spray” or “crack and crevice” straw applicator, making it easier to reach tight spaces where bugs hide.
Home Defense Ant, Roach & Spider Killer by Ortho is a consumer-grade bug spray that helps homeowners get rid of—or prevent—common crawling pests like ants, roaches, and spiders inside their living spaces. It works quickly on contact and leaves a protective layer that can keep killing bugs for a period after application. With proper use, it provides a way to minimize domestic pest problems without needing professional exterminators for routine, light infestations.
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Read MoreOur certified technicians eliminate pests infestations completely and permanently.
Here's what you get:
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Trained experts identify entry points and nesting areas
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Pet and family-friendly methods used
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Targets entire colony, not just visible insects or rodents
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Long-term exclusion strategies
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Proper cleanup and sanitization
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Service warranty and follow-up visits
Complete property assessment within 24 hours
Safe, effective treatment of entire colony
Long-term exclusion and monitoring
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